Fluconazole appears to be a safe and effective treatment for cutaneous leishmaniasis. Diflucan should be stored at room temperature away from moisture and sunlight. Do not stop taking Diflucan without talking to your doctor. Diflucan should be stored at room temperature away from moisture and sunlight. Fluconazole is used for the treatment of serious fungal infections, especially of the central nervous system. Fluconazole has been used in the fungal infection Cryptococcus. Before taking Diflucan, tell your doctor or pharmacist if you are pregnant or could become pregnant during treatment. Fluconazole appears to be a safe and effective treatment for cutaneous leishmaniasis.