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Nexium is usually taken once a day at least one hour before a meal. Nexium is usually taken once a day at least one hour before a meal. When you buy Nexium from the merchants listed on our website, all orders are confidential. Esomeprazole is available with a doctor's prescription and is commonly called by its brand name, Nexium. By excess stomach acid. Esomeprazole capsules should be taken at least one hour before meals and at the same time every day. Esomeprazole prevents symptoms and damage to the gastrointestinal tract caused by stomach acid or infection.