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Strong allergic reactions to Diflucan, although rare, have been reported. Before taking Diflucan, tell your doctor if you are pregnant or could become pregnant during treatment. You may have about how to use Fluconazole. Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. Strong allergic reactions to Diflucan, although rare, have been reported. Do not take Diflucan without first talking to your doctor if you are pregnant or could become pregnant during treatment.