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Beta-blockers. Propranolol is used to prevent migraine, although it is not fully understood how Propranolol works in this area. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and the velocity and extent of myocardial contraction. Propranolol is a competitive antagonist which specifically competes with beta-adrenergic receptor stimulating agents for available beta-receptor sites.

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