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Before taking Diflucan, tell your doctor or pharmacist if you are pregnant or could become pregnant during treatment. Fluconazole has been used in the fungal infection Cryptococcus. Fluconazole is one of the first-line drugs, particularly in treatment of infections. In your body is kept at a constant level. Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. Fluconazole can pass into breast milk and may harm a nursing baby. Diflucan comes with a patient information leaflet.