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Lexapro blocks the re-absorption of serotonin by the first nerve cell. Lexapro affects chemicals in the brain that helps maintain mental balance. Lexapro is actually an updated version of an older anti-depressant called Celexa. Within days of taking Lexapro you will notice an incredible change in your depression symptoms. Lexapro affects chemicals in the brain, is an important factor in the development and severity of depressive symptoms, such as sad mood, fatigue, lack of pleasure, etc. Escitalopram appears to work by increasing the available supply of serotonin.