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Beta-blockers. Propranolol is used to prevent migraine, although it is not fully understood how Propranolol works in this area. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and the velocity and extent of myocardial contraction. Propranolol is a competitive antagonist which specifically competes with beta-adrenergic receptor stimulating agents for available beta-receptor sites. Propranolol should be administered with caution since it may block bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta-adrenergic receptors. Care should be taken if adrenaline is given with Propranolol, as this combination can cause severely high blood pressure and heart failure. Several reports in the published literature describe cases in which Propranolol was used as a suicide agent. Beta-blockers work by blocking beta receptors that are found in various parts of the body.
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