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Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Prednisone and Prednisolone are members of the glucocorticoid class of hormones. Do not stop using Prednisolone suddenly, or you could have unpleasant withdrawal symptoms. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Prednisolone is used for treating leukemia, lymphomas and autoimmune hemolytic anemia. Prednisone to Prednisolone is impaired. Prednisolone is a corticosteroid used to treat various inflammatory and allergy conditions as well as other diseases.