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In order to get the most benefit from it. Metformin comes as a tablet and an extended-release tablet to take by mouth. Most benefit from it. Metformin decreases the amount of glucose you absorb from your food and the amount of sugar produced by cells in the liver. Your food and the amount of glucose in your blood by decreasing sugar production and absorption and helping your body to respond better to insulin, a natural substance that controls the amount of glucose made by your liver. Glucophage should be taken with meals.