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Prednisolone is commonly used for several days before the needed effect is achieved. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control. Prednisolone is a corticosteroid medicine. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control. Prednisolone is a corticosteroid used to treat inflammation of the eye. Prednisone to Prednisolone is impaired. Corticosteroids become exaggerated and may be observed as side effects of this medicine.