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Propranolol is used to prevent migraine, although it is not fully understood how Propranolol works in this area. Treatment should be started with a beta-blocker rather than a diuretic. If you have ischemic heart disease. Propranolol may mask the symptoms of low blood sugar such as increased heart rate, systolic blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped.