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Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Diarrhea have been reported. Levaquin is generally well tolerated however skin rashes, nausea, and diarrhea have been reported. Follow the procedures you are taught when you use a dose. Be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Levofloxacin is effective against a number of gram-positive and gram-negative bacteria.