Research has shown that depression and anxiety disorders could be linked to a chemical imbalance in the brain. Recent studies suggest an increased risk of Paxil birth defects for pregnant women during their first trimester. Avoid drinking alcohol, which can increase some of the side effects of Paroxetine. Recent studies suggest an increased risk of Paxil birth defects for pregnant women during their first trimester. As long as your doctor advises. It is important to take Paxil with breakfast. Paxil should be taken once a day, either in the morning or evening, with or without food. Symptoms associated with an unfavorable mental state need to be excessive and chronic to be considered to have in fact the medical problem of a major depressive disorder, as stated by others. You, you are now taking an FDA-approved medication proven safe and effective for long-term use and is well tolerated.