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A serious illness, fever or infection, or if you have a fungal infection anywhere in your body. Prednisolone is a corticosteroid used to treat various inflammatory and allergy conditions as well as other diseases. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Prednisolone is used for treating several types of arthritis systemic lupus, allergic reactions, asthma and severe psoriasis.