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Celexa is the newest antidepressant to be approved by theFDA. Celexa insomnia may be a side effect from this drug prolonging serotonin's action within the brain. Do not stop using Celexa without first talking to your doctor. Ssri medications affect the levels of serotonin in the brain called serotonin. Celexa may cause suicidal thoughts or ideation. After stopping an MAO inhibitor. Celexa may cause suicidal thoughts or ideation.