Glucophage does not increase the body's production of insulin. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. Glucophage does not increase the body's production of insulin. Use this medication regularly in order to get the most benefit from it. Glucophage lowers the amount of sugar that your liver makes and that your stomach absorbs. Metformin belongs to the class of drugs known as biguanides. Metformin reduces the amount of sugar that your liver makes and that your stomach absorbs.