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Valacyclovir pronunciation: "Valaciclovir is most effective when taken within 24 hours of the start of symptoms. Instead of treating each outbreak as it occurs, taking Valtrex once daily, whether or not you have symptoms, can reduce the number of incidences. Once daily, whether or not you have symptoms, can reduce the number of outbreaks experienced in a year's time. If taken soon enough. Valtrex is most effective if it is started within 48 hours of when the rash first appears. To practice safe sex for the rest of their life. Anyone who has been diagnosed with genital herpes will need to practice safe sex for the rest of your life."